Abstract
Faropenem demonstrated low MICs (< or = 1 microg/ml) for all penicillin-susceptible and nonsusceptible pneumococci and exhibited very strong abilities to bind to Streptococcus pneumoniae penicillin-binding proteins (PBPs), except for PBP2X. The lower faropenem affinity for PBP2X did not affect MICs for any strains tested, and only imipenem had lower MICs, with much lower binding affinities for all PBPs tested, than faropenem.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Anti-Bacterial Agents* / metabolism
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Anti-Bacterial Agents* / pharmacology
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Bacterial Proteins / metabolism
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Humans
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Microbial Sensitivity Tests
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Penicillin Resistance
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Penicillin-Binding Proteins / chemistry
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Penicillin-Binding Proteins / genetics
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Penicillin-Binding Proteins / metabolism*
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Streptococcus pneumoniae / drug effects*
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Streptococcus pneumoniae / metabolism*
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beta-Lactams* / metabolism
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beta-Lactams* / pharmacology
Substances
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Anti-Bacterial Agents
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Bacterial Proteins
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Penicillin-Binding Proteins
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beta-Lactams
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fropenem